Seyfullah HACIMÜFTÜOĞLU was born in 1960 in the Çaykara district of Trabzon. He graduated from the Faculty of Political Sciences at Ankara University in 1984. In 1985, he began his career in public administration as a District Governor Candidate at the Governorship of Trabzon.

Married and the father of two children, Hacımüftüoğlu served as District Governor in the districts of Sakarya-Taraklı, Hakkâri-Şemdinli, Kastamonu-Doğanyurt, Şanlıurfa-Ceylanpınar, Denizli-Serinhisar, and Manisa-Akhisar throughout his career.

In 2005, he was appointed Deputy President of the State Personnel Presidency. Between 2007 and 2009, he served as Deputy Undersecretary of the Prime Ministry. During this period, he also held the position of Chairman of the Board of Directors of the Press Advertising Agency.

On August 29, 2009, he was appointed Governor of Rize; and on May 19, 2012, by Presidential decree, he was appointed Undersecretary of the Ministry of Interior. On September 16, 2014, he was appointed Secretary-General of the National Security Council.

As of May 27, 2025, he is serving as a Member of the Board of Directors at TUSAŞ – Turkish Aerospace Industries Inc.